Effects of Exercise and Cardiorespiratory Fitness on Estrogen Metabolism in Postmenopausal Women.

ABSTRACT:

Background

Lowering endogenous estrogen levels is one mechanism whereby physical activity may lower postmenopausal breast cancer risk. Several prospective studies have suggested that increased 2-hydroxylation of estrogens may also reduce postmenopausal breast cancer risk, but whether or not exercise alters estrogen metabolism through this mechanism is unclear.

Methods

We measured total circulating concentrations of parent estrogens (estrone and estradiol) and 13 estrogen metabolites, including glucuronidated, sulfated, and unconjugated forms, by stable isotope dilution LC/MS-MS in 153 postmenopausal women randomized to 12 months of moderate-to-vigorous exercise and 153 controls. We also explored associations with cardiorespiratory fitness measured by treadmill.

Results

SUBMITTER: Matthews CE 

PROVIDER: S-EPMC7899052 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature