Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles.

ABSTRACT: Patients with polycystic kidney disease (PKD) are characterized with uncontrolled hypertension. Hypertension in PKD is a ciliopathy, an abnormal function and/or structure of primary cilia. Primary cilia are cellular organelles with chemo and mechanosensory roles. In the present studies, we designed a cilia-targeted (CT) delivery system to deliver fenoldopam specifically to the primary cilia. We devised the iron oxide nanoparticle (NP)-based technology for ciliotherapy. Live imaging confirmed that the CT-Fe₂O₃-NPs specifically targeted primary cilia in cultured cells in vitro and vascular endothelia in vivo. Importantly, the CT-Fe₂O₃-NPs enabled the remote control of the movement and function of a cilium with an external magnetic field, making the

SUBMITTER: Pala R 

PROVIDER: S-EPMC7899146 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature