AP-1 imprints a reversible transcriptional programme of senescent cells.

ABSTRACT: Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction have been identified, the dynamics, epigenetic mechanisms and regulatory networks defining senescence competence, induction and maintenance remain poorly understood, precluding the deliberate therapeutic targeting of senescence for health benefits. Here, we examined the possibility that the epigenetic state of enhancers determines senescent cell fate. We explored this by generating time-resolved transcriptomes and epigenome profiles during oncogenic RAS-induced senescence and validating central findings in different cell biology and disease models of senescence. Through integrative analysis and functional validation, we reveal links between enhan

SUBMITTER: Martinez-Zamudio RI 

PROVIDER: S-EPMC7899185 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature