Freeze-dried plasma for major trauma - Systematic review and meta-analysis.

ABSTRACT:

Background

Treatment of acute trauma coagulopathy has shifted toward rapid replacement of coagulation factors with frozen plasma (FP). There are logistic difficulties in providing FP. Freeze-dried plasma (FDP) may have logistical advantages including easier storage and rapid preparation time. This review assesses the feasibility, efficacy, and safety of FDP in trauma.

Study design and methods

Studies were searched from Medline, Embase, Cochrane Controlled Trials Register, ClinicalTrials.gov, and Google Scholar. Observational and randomized controlled trials (RCTs) assessing FDP use in trauma were included. Trauma animal models addressing FDP use were also included. Bias was assessed using validated tools. Primary outcome was efficacy, and secondary outcomes were feasibility

SUBMITTER: Mok G 

PROVIDER: S-EPMC7899224 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature