Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery.

ABSTRACT:

Background

Blood transfusion is a lifesaving intervention for millions of recipients worldwide every year. Storing blood makes this possible but also promotes a series of alterations to the metabolism of the stored erythrocyte. It is unclear whether the metabolic storage lesion is correlated with clinically relevant outcomes and whether strategies aimed at improving the metabolic quality of stored units, such as hypoxic storage, ultimately improve performance in the transfused recipient.

Study design and methods

Twelve healthy donor volunteers were recruited in a two-arm cross-sectional study, in which each subject donated 2 units to be stored under standard (normoxic) or hypoxic conditions (Hemanext technology). End-of-storage measurements of hemolysis and autologous posttr

SUBMITTER: DʼAlessandro A 

PROVIDER: S-EPMC7899235 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature