Quantifying epidemiological drivers of gambiense human African Trypanosomiasis across the Democratic Republic of Congo.

ABSTRACT: Gambiense human African trypanosomiasis (gHAT) is a virulent disease declining in burden but still endemic in West and Central Africa. Although it is targeted for elimination of transmission by 2030, there remain numerous questions about the drivers of infection and how these vary geographically. In this study we focus on the Democratic Republic of Congo (DRC), which accounted for 84% of the global case burden in 2016, to explore changes in transmission across the country and elucidate factors which may have contributed to the persistence of disease or success of interventions in different regions. We present a Bayesian fitting methodology, applied to 168 endemic health zones (∼100,000 population size), which allows for calibration of a mechanistic gHAT model to case data (from the World H

SUBMITTER: Crump RE 

PROVIDER: S-EPMC7899378 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature