Early Antibiotic Administration Is Associated with a Reduced Infection Risk When Combined with Primary Wound Closure in Patients with Open Tibia Fractures.

ABSTRACT:

Background

Early administration of antibiotics and wound coverage have been shown to decrease the deep infection risk in all patients with Type 3 open tibia fractures. However, it is unknown whether early antibiotic administration decreases infection risk in patients with Types 1, 2, and 3A open tibia fractures treated with primary wound closure.

Questions/purposes

(1) Does decreased time to administration of the first dose of antibiotics decrease the deep infection risk in all open tibia fractures with primary wound closure? (2) What patient demographic factors are associated with an increased deep infection risk in Types 1, 2, and 3A open tibia fractures with primary wound closure?

Methods

We identified 361 open tibia fractures over a 5-year period at a Level I regi

SUBMITTER: Zuelzer DA 

PROVIDER: S-EPMC7899592 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature