Circulating follicular helper T cells and subsets are associated with immune response to hepatitis B vaccination.

ABSTRACT: Around 5-10% of healthy vaccinees lack or produce an inadequate antibody response following receipt of a standard hepatitis B vaccination regimen. Studying immune response to hepatitis B vaccination could promote researches of immunological events contributing to this poor response. To address this, we investigated follicular helper T (Tfh) cells and firstly demonstrated similar kinetics between circulating Tfh (cTfh) cells and Tfh cells derived from mice spleen after hepatitis B vaccination. And cTfh cells were positively associated with anti-HBs at one week after vaccination (D7). Furthermore, we found PBMCs stimulated by HBsAg showed preferential activation of CXCR3^- Tfh cells subsets in vitro. The expression of transcription factor BCL6 in CD4⁺ T cell signi

SUBMITTER: Yin M 

PROVIDER: S-EPMC7899680 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature