Saliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019.

ABSTRACT:

Background

Pediatric COVID-19 studies exploring the relationships between NPS and saliva viral loads, clinical and immunological profiles are lacking.

Methods

Demographics, immunological profiles, nasopharyngeal swab (NPS), and saliva samples collected on admission, and hospital length of stay (LOS) were assessed in children below 18 years with COVID-19.

Findings

91 patients were included between March and August 20 20. NPS and saliva viral loads were correlated (r = 0.315, p = 0.01). Symptomatic patients had significantly higher NPS and saliva viral loads than asymptomatic patients. Serial NPS and saliva viral load measurements showed that the log₁₀ NPS (r = -0.532, p < 0.001) and saliva (r = -0.417, p < 0.001) vir

SUBMITTER: Chua GT 

PROVIDER: S-EPMC7899683 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature