SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis.

ABSTRACT:

Rationale

Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and features of plaque instability, in part, through lipid-mediated oxidative DNA damage and telomere dysfunction. SIRT6 (Sirtuin 6) is a nuclear deacetylase involved in DNA damage response signaling, inflammation, and metabolism; however, its role in regulating VSMC senescence and atherosclerosis is unclear.

Objective

We examined SIRT6 expression in human VSMCs, the role, regulation, and downstream pathways activated by SIRT6, and how VSMC SIRT6 regulates atherogenesis.

Methods and results

SIRT6 protein, but not mRNA, expression was markedly reduced in VSMCs in human and mouse atherosclerotic plaques, and in human VSMCs derived from plaques or undergoing replicative or palmitate-induced

SUBMITTER: Grootaert MOJ 

PROVIDER: S-EPMC7899748 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature