Mini-review: Trophic interactions between cancer cells and primary afferent neurons.

ABSTRACT: Cancer neurobiology is an emerging discipline that inevitably unfurls new perspectives in oncology. The role that nerves play in cancer progression resonates with the long-reported dependency of tumors on neuro-molecular mechanisms that remain insufficiently elucidated. Whereas interactions between neurotrophic growth factors and receptors have been heavily studied in the nervous system, their expression in cancers and their impact on tumor cell growth and metastasis through their corresponding signaling pathways has been undervalued. Accumulating evidence suggests that trophic factors released by nerves strongly influence tumor development and that this neural contribution appears to not only play a stimulatory role but also function as an essential part of the tumor's microenvironment. T

SUBMITTER: Hunt PJ 

PROVIDER: S-EPMC7899767 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature