Consumption of red meat, genetic susceptibility, and risk of LADA and type 2 diabetes.

ABSTRACT:

Purpose

Red meat consumption is positively associated with type 1 (T1D) and type 2 (T2D) diabetes. We investigated if red meat consumption increases the risk of latent autoimmune diabetes in adults (LADA) and T2D, and potential interaction with family history of diabetes (FHD), HLA and TCF7L2 genotypes.

Methods

Analyses were based on Swedish case-control data comprising incident cases of LADA (n = 465) and T2D (n = 1528) with matched, population-based controls (n = 1789; n = 1553 in genetic analyses). Multivariable-adjusted ORs in relation to self-reported processed and unprocessed red meat intake were estimated by conditional logistic regression models. Attributable proportion (AP) due to interaction was used to assess departure from additivity of effects.

Results

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SUBMITTER: Lofvenborg JE 

PROVIDER: S-EPMC7900036 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature