Three-dimensional structure of human cyclooxygenase (hCOX)-1.

ABSTRACT: The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurological and neurodegenerative diseases only recently. COXs catalyze the first step in the biosynthesis of prostaglandins (PGs) and are among the most important mediators of inflammation. All published structural work on COX-1 deals with the ovine isoenzyme, which is easier to produce in milligram-quantities than the human enzyme and crystallizes readily. Here, we report the long-sought structure of the human cyclooxygenase-1 (hCOX-1) that we refined to an R/R_free of 20.82/26.37, at 3.36 Å resolution. hCOX-1 structure provides a detailed pictur

SUBMITTER: Miciaccia M 

PROVIDER: S-EPMC7900114 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature