Epigraph hemagglutinin vaccine induces broad cross-reactive immunity against swine H3 influenza virus.

ABSTRACT: Influenza A virus infection in swine impacts the agricultural industry in addition to its zoonotic potential. Here, we utilize epigraph, a computational algorithm, to design a universal swine H3 influenza vaccine. The epigraph hemagglutinin proteins are delivered using an Adenovirus type 5 vector and are compared to a wild type hemagglutinin and the commercial inactivated vaccine, FluSure. In mice, epigraph vaccination leads to significant cross-reactive antibody and T-cell responses against a diverse panel of swH3 isolates. Epigraph vaccination also reduces weight loss and lung viral titers in mice after challenge with three divergent swH3 viruses. Vaccination studies in swine, the target species for this vaccine, show stronger levels of cross-reactive antibodies and T-cell responses afte

SUBMITTER: Bullard BL 

PROVIDER: S-EPMC7900167 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature