Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation.

ABSTRACT: Diversity of the gut microbiome is associated with higher response rates for cancer patients receiving immunotherapy but has not been investigated in patients receiving radiation therapy. Additionally, current studies investigating the gut microbiome and outcomes in cancer patients may not have adjusted for established risk factors. Here, we sought to determine if diversity and composition of the gut microbiome was independently associated with survival in cervical cancer patients receiving chemoradiation. Our study demonstrates that the diversity of gut microbiota is associated with a favorable response to chemoradiation. Additionally, compositional variation among patients correlated with short term and long-term survival. Short term survivor fecal samples were significantly enriched in

SUBMITTER: Sims TT 

PROVIDER: S-EPMC7900251 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature