Role of Blood Pressure Management in Stroke Prevention: A Systematic Review and Network Meta-Analysis of 93 Randomized Controlled Trials.

ABSTRACT:

Background and purpose

The present study aimed to compare the efficacy and tolerability of different blood pressure (BP)-lowering strategies.

Methods

Randomized controlled trials that compared various antihypertensive treatments and stroke outcomes were included. Eligible trials were categorized into three scenarios: single or combination antihypertensive agents against placebos; single or combination agents against other agents; and different BP-lowering targets. The primary efficacy outcome was the risk reduction pertaining to strokes. The tolerability outcome was the withdrawal of drugs, owing to drug-related side effects (PROSPERO registration number CRD42018118454 [20/12/2018]).

Results

The present study included 93 trials (average follow-up duration, 3.3 years).

SUBMITTER: Zhong XL 

PROVIDER: S-EPMC7900391 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature