Different Modular Organization Between Early Onset and Late Onset Depression: A Study Base on Granger Causality Analysis.

ABSTRACT: Background: Modular organization reflects the activity patterns of our brain. Different disease states may lead to different activity patterns and clinical features. Early onset depression (EOD) and late onset depression (LOD) share the same clinical symptoms, but have different treatment strategies and prognosis. Thus, explored the modular organization of EOD and LOD might help us understand their pathogenesis. Method: The study included 82 patients with late life depression (EOD 40, LOD 42) and 90 healthy controls. We evaluated the memory, executive function and processing speed and performed resting-stage functional MRI for all participants. We constructed a functional network based on Granger causality analysis and carried out modularity, normalized mutual information (NM

SUBMITTER: Mai N 

PROVIDER: S-EPMC7900556 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature