Low Expression of the Polycomb Protein RING1 Predicts Poor Prognosis in Human Breast Cancer.

ABSTRACT:

Background

To date, breast cancer remains the most common malignant tumor in women. In recent years, a growing number of studies on polycomb proteins have been conducted. The Ring finger protein1 (RING1), an essential component of the polycomb family of proteins, plays vital roles in the tumorigenesis of various cancer types. However, further research is required in determining RING1 expression and prognostic value in breast cancer.

Method

RING1 expression level in multiple cancer types was evaluated using the XENA and UALCAN databases. Real-time quantitative PCR (real-time qPCR) and immunohistochemistry (IHC) were used to confirm this expression. The prognostic value was analyzed using our follow-up data and the Kaplan-Meier plotter website. RING1 co-expressed genes and its

SUBMITTER: Gao S 

PROVIDER: S-EPMC7900562 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature