Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study.

ABSTRACT:

Objectives

Recent studies suggested obesity to be a possible risk factor for COVID-19 disease in the wake of the coronavirus (SARS-CoV-2) infection. However, the causality and especially the role of body fat distribution in this context is still unclear. Thus, using a univariable as well as multivariable two-sample Mendelian randomization (MR) approach, we investigated for the first time the causal impact of body composition on the susceptibility and severity of COVID-19.

Methods

As indicators of overall and abdominal obesity we considered the measures body mass index (BMI), waist circumference (WC), and trunk fat ratio (TFR). Summary statistics of genome-wide association studies (GWASs) for these body composition measures were drawn from the GIANT consortium and UK Biobank,

SUBMITTER: Freuer D 

PROVIDER: S-EPMC7900753 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature