Epidemiology and persistence of rhinovirus in pediatric lung transplantation.

ABSTRACT:

Background

Infection with rhinovirus (HRV) occurs following pediatric lung transplantation. Prospective studies documenting frequencies, persistence, and progression of HRV in this at-risk population are lacking.

Methods

In the Clinical Trials in Organ Transplant in Children prospective observational study, we followed 61 lung transplant recipients for 2 years. We quantified molecular subtypes of HRV in serially collected nasopharyngeal (NP) and bronchoalveolar lavage (BAL) samples and correlated them with clinical characteristics.

Results

We identified 135 community-acquired respiratory infections (CARV) from 397 BAL and 480 NP samples. We detected 93 HRV events in 42 (68.8%) patients, 22 of which (23.4%) were symptomatic. HRV events were contiguous with different ge

SUBMITTER: Ammerman E 

PROVIDER: S-EPMC7900771 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature