A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation.

ABSTRACT:

Background & aims

p21-activated kinase-1 (PAK1) belongs to a family of serine-threonine kinases and contributes to cellular pathways such as nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), and Wingless-related integration site(Wnt)/β-catenin, all of which are involved in intestinal homeostasis. Overexpression of PAK1 is linked to inflammatory bowel disease as well as colitis-associated cancer (CAC), and similarly was observed in interleukin (IL)10 knockout (KO) mice, a model of colitis and CAC. Here, we tested the effects of PAK1 deletion on intestinal inflammation and carcinogenesis in IL10 KO mice.

Methods

IL10/PAK1 double-knockout (DKO) mice were generated and development of colitis and CAC was

SUBMITTER: Frick A 

PROVIDER: S-EPMC7900837 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature