Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort.

ABSTRACT:

Purpose

Refractive errors, particularly myopia, are common and a leading cause of blindness. This study aimed to explore associations between medications and refractive error in an aging adult cohort and to determine whether childhood-onset refractive errors predict future medication use to provide novel insights into disease mechanisms.

Methods

The study compared the spherical equivalent values measured in 102,318 UK Biobank participants taking the 960 most commonly used medications. The strengths of associations were evaluated against the self-reported age of spectacle wear. The causality of refractive error changes was inferred using sensitivity and Mendelian randomization analyses.

Results

Anti-glaucoma drugs were associated with 1 to 2 diopters greater myopic ref

SUBMITTER: Patasova K 

PROVIDER: S-EPMC7900881 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature