Lifetime antimicrobial use is associated with weight status in early adolescence-A register-based cohort study.

ABSTRACT:

Background

Antimicrobial agents (AMs) are the most prescribed drugs to children. Early and repeated exposure to AMs in infancy is associated with increased risk of childhood overweight and obesity.

Aims

We extended the investigation of AMs use, from birth to early adolescence, and evaluated their association with weight status.

Materials & methods

A total of 10093 children from Finnish Health in Teens cohort (Fin-HIT) with register-based data on AMs purchases and measured weight status at the mean age of 11.2 y (SD 0.82) were included in the study. The key exposures were the number AM purchases at a given age or the sum of these during the entire follow-up time to describe lifetime exposure / use. Outcome was weight status in early adolescence defined with Internation

SUBMITTER: Figueiredo RAO 

PROVIDER: S-EPMC7900955 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature