Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats.

ABSTRACT: Acute swim stress results in the robust production of several neuroactive steroids, which act as mediators of the stress response. These steroids include glucocorticoids, and positive GABA_A receptor modulatory steroids such as allopregnanolone and tetrahydrocorticosterone (THDOC), which potentiate inhibitory GABA signalling, thereby playing a role in the negative control of the hypothalamic-pituitary-adrenal (HPA) axis. Prenatally stressed (PNS) offspring exhibit increased vulnerability to stress-related disorders and frequently display exaggerated HPA axis responses to stressors during adulthood, which may be a result of reduced neuroactive steroid production and consequently inhibitory signalling. Here, we investigated whether exposure of rats to prenatal social stress from ge

SUBMITTER: Sze Y 

PROVIDER: S-EPMC7900968 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature