Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project.

ABSTRACT:

Background & aims

Gallbladder cancer (GBC) is known to have a female predominance while other biliary tract cancers (BTCs) have a male predominance. However, the role of female reproductive factors in BTC etiology remains unclear.

Methods

We pooled data from 19 studies of >1.5 million women participating in the Biliary Tract Cancers Pooling Project to examine the associations of parity, age at menarche, reproductive years, and age at menopause with BTC. Associations for age at menarche and reproductive years with BTC were analyzed separately for Asian and non-Asian women. Hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, stratified by study.

Results

During 21,681,798 person-years of follow-up, 875 cases of GBC, 379 of intrahepatic b

SUBMITTER: Jackson SS 

PROVIDER: S-EPMC7901003 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature