M⁶A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells.

ABSTRACT: N⁶-methyladenosine (m⁶A) has emerged as the most abundant mRNA modification that regulates gene expression in many physiological processes. m⁶A modification in RNA controls cellular proliferation and pluripotency and has been implicated in the progression of multiple disease states, including cancer. RNA m⁶A methylation is controlled by a multiprotein "writer" complex including the enzymatic factor methyltransferase-like protein 3 (METTL3) that regulates methylation and two "eraser" proteins, RNA demethylase ALKBH5 (ALKBH5) and fat mass- and obesity-associated protein (FTO), that demethylate m⁶A in transcripts. FTO can also demethylate N⁶,2'-O-dimethyladenosine (m⁶A_m), which is foun

SUBMITTER: Huff S 

PROVIDER: S-EPMC7901021 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature