Coordination of hippocampal theta and gamma oscillations relative to spatial active avoidance reflects cognitive outcome after febrile status epilepticus.

ABSTRACT: Cognitive deficits may arise from a variety of genetic alterations and neurological insults that impair neural coding mechanisms and the routing of neural information underpinning learning and memory. Slow and medium gamma oscillations underpin memory recall and sensorimotor processing and represent dynamic inputs at CA1 synapses. Febrile status epilepticus (FSE) can lead to increased risk for temporal lobe epilepsy and enduring cognitive impairments. In a rodent model, we assessed how FSE alters hippocampal CA1 signals relative to spatial task performance and serve as a readout of synaptic input efficacy. The power of theta (5-12 Hz), slow gamma (30-50 Hz), and medium gamma (70-90 Hz) differentially interact with respect to cognitive demands during active avoidance behavior on a rotating

SUBMITTER: Barry JM 

PROVIDER: S-EPMC7901024 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature