Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord.

ABSTRACT: Olig2 is an important transcription factor essential for the specification and differentiation of oligodendrocytes as well as astrocytes and neurons during developmental stages. However, Olig2 distribution pattern and its relationship among different types of glial cells in the adult central nervous system (CNS) are not well characterized. Here, we systematically examined Olig2 expression pattern in combination with major markers of neurons and glial cells throughout the brain and spinal cord in the adult mice. As expected, Olig2 is universally expressed in oligodendrocytes and oligodendrocyte precursor cells (OPCs), but not in neurons or microglia. Interestingly, we discover a subpopulation of Olig2⁺ astrocytes that are highly enriched in some specific regions including the olf

SUBMITTER: Wang H 

PROVIDER: S-EPMC7901088 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature