High-dose opioid utilization and mortality among individuals initiating hemodialysis.

ABSTRACT:

Background

Individuals undergoing hemodialysis in the United States frequently report pain and receive three-fold more opioid prescriptions than the general population. While opioid use is appropriate for select patients, high-dose utilization may contribute to an increased risk of death due to possible accumulation of opioid metabolites.

Methods

We studied high-dose opioid utilization (≥120 morphine milligram equivalents [MME] per day) among adults initiating hemodialysis in the United States between 2007 and 2014 using national registry data. We calculated the cumulative incidence (%) of high-dose utilization and depicted trends in the average percentage of days individuals were exposed to opioids. We used adjusted Cox proportional hazards models to identify which opioid d

SUBMITTER: Daubresse M 

PROVIDER: S-EPMC7901089 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature