HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis.

ABSTRACT:

Objective

It is well established that patients with systemic sclerosis (SSc) have a disrupted lipid profile and an increased cardiovascular risk. Cholesterol efflux capacity (CEC), the ability of high-density lipoprotein (HDL)-cholesterol to accept cholesterol from macrophages, has been linked to cardiovascular events. The aim of this study was to establish whether CEC and lipid profile were impaired in SSc patients with respect to controls and whether these changes were associated with disease-related data.

Methods

Cross-sectional study encompassed 188 individuals: 73 SSc patients and 115 controls. CEC, using an in vitro assay, and lipoprotein serum concentrations were assessed in patients and controls. A multivariable analysis was performed to study the differences in CEC

SUBMITTER: Ferraz-Amaro I 

PROVIDER: S-EPMC7901093 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature