CircAGAP1 promotes tumor progression by sponging miR-15-5p in clear cell renal cell carcinoma.

ABSTRACT:

Background

Accumulating evidence has revealed that circular RNAs (circRNAs), as novel noncoding RNAs, play critical roles in carcinogenesis and tumor progression. However, the functions and molecular mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) are largely unknown.

Methods

The expression and functions of circAGAP1 were identified in clinical samples, ccRCC cells and in vivo animal models. The molecular mechanism of circAGAP1 was investigated by fluorescence in situ hybridization, RNA immunoprecipitation and luciferase assays.

Results

circAGAP1 (circ0058792) expression was significantly upregulated in ccRCC tissues compared to adjacent nontumor tissues. Moreover, the expression of circAGAP1 was closely related to the tumor size, nuclear grade and c

SUBMITTER: Lv Q 

PROVIDER: S-EPMC7901094 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature