Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation.

ABSTRACT:

Background

Claudin-2 expression is upregulated in multiple cancers and promotes cancer malignancy. Remarkably, the regulation of claudin-2 expression in kidney cell lines contrasts its reported regulation in other organs. However, claudin-2 role in renal clear cell carcinoma (RCC) remains unknown despite its predominant expression in the proximal tubular epithelium (PTE), the site of RCC origin.

Methods

Publicly available and independent patient databases were examined for claudin-2 association with RCC. The novel protein function was validated in vitro and in vivo by gain or loss of function assays. Mechanistic results were concluded by Mass spectroscopy, immunoprecipitation and mutational studies, and functional evaluations.

Results

We show that the significant decr

SUBMITTER: Kumar B 

PROVIDER: S-EPMC7901196 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature