Systemic administration of β-glucan induces immune training in microglia.

ABSTRACT:

Background

An innate immune memory response can manifest in two ways: immune training and immune tolerance, which refers to an enhanced or suppressed immune response to a second challenge, respectively. Exposing monocytes to moderate-to-high amounts of bacterial lipopolysaccharide (LPS) induces immune tolerance, whereas fungal β-glucan (BG) induces immune training. In microglia, it has been shown that different LPS inocula in vivo can induce either immune training or tolerance. Few studies focused on impact of BG on microglia and were only performed in vitro. The aim of the current study was to determine whether BG activates and induces immune memory in microglia upon peripheral administration in vivo.

Methods

Two experimental designs were used. In the acute design, mice rec

SUBMITTER: Heng Y 

PROVIDER: S-EPMC7901224 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature