Dataset Information

Assessing the impact of COVID-19 on liver cancer management (CERO-19).

ABSTRACT:

Background & aims

The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic.

Methods

An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave.

Results

Ninety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%, 17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37).

Conclusions

The first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making.

Lay summary

The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes.

SUBMITTER: Munoz-Martinez S

PROVIDER: S-EPMC7901294 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Publications

Assessing the impact of COVID-19 on liver cancer management (CERO-19).

Muñoz-Martínez Sergio S Sapena Victor V Forner Alejandro A Nault Jean-Charles JC Sapisochin Gonzalo G Rimassa Lorenza L Sangro Bruno B Bruix Jordi J Sanduzzi-Zamparelli Marco M Hołówko Wacław W El Kassas Mohamed M Mocan Tudor T Bouattour Mohamed M Merle Philippe P Hoogwater Frederik J H FJH Alqahtani Saleh A SA Reeves Helen L HL Pinato David J DJ Giorgakis Emmanouil E Meyer Tim T Villadsen Gerda Elisabeth GE Wege Henning H Salati Massimiliano M Mínguez Beatriz B Di Costanzo Giovan Giuseppe GG Roderburg Christoph C Tacke Frank F Varela María M Galle Peter R PR Alvares-da-Silva Mario Reis MR Trojan Jörg J Bridgewater John J Cabibbo Giuseppe G Toso Christian C Lachenmayer Anja A Casadei-Gardini Andrea A Toyoda Hidenori H Lüdde Tom T Villani Rosanna R Matilla Peña Ana María AM Guedes Leal Cassia Regina CR Ronzoni Monica M Delgado Manuel M Perelló Christie C Pascual Sonia S Lledó José Luis JL Argemi Josepmaria J Basu Bristi B da Fonseca Leonardo L Acevedo Juan J Siebenhüner Alexander R AR Braconi Chiara C Meyers Brandon M BM Granito Alessandro A Sala Margarita M Rodríguez-Lope Carlos C Blaise Lorraine L Romero-Gómez Manuel M Piñero Federico F Gomez Dhanny D Mello Vivianne V Pinheiro Alves Rogerio Camargo RC França Alex A Branco Fernanda F Brandi Giovanni G Pereira Gustavo G Coll Susanna S Guarino Maria M Benítez Carlos C Anders Maria Margarita MM Bandi Juan C JC Vergara Mercedes M Calvo Mariona M Peck-Radosavljevic Markus M García-Juárez Ignacio I Cardinale Vincenzo V Lozano Mar M Gambato Martina M Okolicsanyi Stefano S Morales-Arraez Dalia D Elvevi Alessandra A Muñoz Alberto E AE Lué Alberto A Iavarone Massimo M Reig Maria M

JHEP reports : innovation in hepatology 20210223 3

<h4>Background & aims</h4>The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic.<h4>Methods</h4>An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the f ...[more]

PMID: 33644725

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Dataset Information

Assessing the impact of COVID-19 on liver cancer management (CERO-19).

Background & aims

Methods

Results

Conclusions

Lay summary

Publications

Assessing the impact of COVID-19 on liver cancer management (CERO-19).

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