TET2 mutations in acute myeloid leukemia: a comprehensive study in patients of Sindh, Pakistan.

ABSTRACT:

Background

The tet oncogene family member 2 (TET2) gene has been reported to be involved in DNA methylation and epigenetic regulation in acute myeloid leukemia (AML). Various studies have proven functional role of TET2 mutations in AML. We herein studied the frequency and genotype-phenotype correlation of TET2 gene in AML patients in Sindh, Pakistan.

Patients and methods

The current study was carried out at Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan, in collaboration with National Institute of Blood Disease & Bone Marrow Transplant, Karachi, Pakistan, during the period from June 2019 to June 2020. A total of 130 patients diagnosed with AML were screened for TET2 mutations. Whole exome sequencing of 14 individuals was carri

SUBMITTER: Shaikh ARK 

PROVIDER: S-EPMC7901355 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature