Associations of Genetic Variants Contributing to Gut Microbiota Composition in Immunoglobin A Nephropathy.

ABSTRACT: The gut microbiota has been implicated in immunoglobin A nephropathy (IgAN) because the intestinal immune response is assumed to be one of the disease triggers. Since the microbial composition is heritable, we hypothesize that genetic variants controlling gut microbiota composition may be associated with susceptibility to IgAN or clinical phenotypes. A total of 175 gut-microbiome-associated genetic variants were retrieved from the Genome-Wide Association Study (GWAS) Catalog. Genetic associations were examined in 1,511 patients with IgAN and 4,469 controls. Subphenotype associations and microbiome annotations were undertaken for a better understanding of how genes shaped phenotypes. Likely candidate microbes suggested in genetic associations were validated using 16S rRNA gene sequencing in

SUBMITTER: He JW 

PROVIDER: S-EPMC7901477 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature