Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis.

ABSTRACT:

Purpose

To study variation in, and clinical impact of high Therapy Intensity Level (TIL) treatments for elevated intracranial pressure (ICP) in patients with traumatic brain injury (TBI) across European Intensive Care Units (ICUs).

Methods

We studied high TIL treatments (metabolic suppression, hypothermia (< 35 °C), intensive hyperventilation (PaCO₂ < 4 kPa), and secondary decompressive craniectomy) in patients receiving ICP monitoring in the ICU stratum of the CENTER-TBI study. A random effect logistic regression model was used to determine between-centre variation in their use. A propensity score-matched model was used to study the impact on outcome (6-months Glasgow Outcome Score-extended (GOSE)), whilst adjusting for case-mix severity, signs of brain herniatio

SUBMITTER: Huijben JA 

PROVIDER: S-EPMC7901510 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature