Major Update: Remdesivir for Adults With COVID-19 : A Living Systematic Review and Meta-analysis for the American College of Physicians Practice Points.

ABSTRACT:

Background

Remdesivir is being studied and used for treatment of coronavirus disease 2019 (COVID-19).

Purpose

To update a previous review of remdesivir for adults with COVID-19, including new meta-analyses of patients with COVID-19 of any severity compared with control.

Data sources

Several sources from 1 January 2020 through 7 December 2020.

Study selection

English-language, randomized controlled trials (RCTs) of remdesivir for COVID-19. New evidence is incorporated by using living review methods.

Data extraction

1 reviewer abstracted data; a second reviewer verified the data. The Cochrane Risk of Bias Tool and GRADE (Grading of Recommendations Assessment, Development and Evaluation) method were used.

Data synthesis

The update includes 5 RCTs, in

SUBMITTER: Kaka AS 

PROVIDER: S-EPMC7901604 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature