FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity.

ABSTRACT: Proteostasis collapses during aging resulting, among other things, in the accumulation of damaged and aggregated proteins. The proteasome is the main cellular proteolytic system and plays a fundamental role in the maintenance of protein homeostasis. Our previous work has demonstrated that senescence and aging are related to a decline in proteasome content and activities, while its activation extends lifespan in vitro and in vivo in various species. However, the mechanisms underlying this age-related decline of proteasome function and the down-regulation in expression of its subunits remain largely unclear. Here, we demonstrate that the Forkhead box-O1 (FoxO1) transcription factor directly regulates the expression of a 20S proteasome catalytic subunit and, hence, proteasome ac

SUBMITTER: Kapetanou M 

PROVIDER: S-EPMC7901890 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature