Evolution of Apathy in Early Parkinson's Disease: A 4-Years Prospective Cohort Study.

ABSTRACT: Objective: We investigated the prevalence, evolution, associated factors, and risk factors of apathy in a cohort of patients with early-stage Parkinson's disease (PD), who underwent a 4-years prospective follow-up. Methods: This study included 188 patients with PD (baseline disease duration <3 years) who underwent an annual evaluation using the Lille Apathy Rating Scale (LARS). Based on the cut-off value of -21 observed on the LARS, patients were categorized as PD with and without apathy. The generalized estimating equations (GEE) model was utilized to determine the factors associated with apathy, and the Cox proportional-hazards regression model was used to determine the predictors of apathy. Results: Apathy increased from a baseline rate of 18.6-28.8% after 4 years;

SUBMITTER: Ou R 

PROVIDER: S-EPMC7901914 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature