Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis.

ABSTRACT: Purpose: Exercise training reveals high potential to beneficially impact cognitive performance in persons with multiple sclerosis (pwMS). Research indicates that high-intensity interval training (HIIT) has potentially higher effects on physical fitness and cognition compared to moderate continuous exercise. This study (i) compares the effects of a 3-week HIIT and moderate continuous exercise training on cognitive performance and cardiorespiratory fitness of pwMS in an overall analysis and (ii) investigates potential effects based on baseline cognitive status in a subgroup analysis. Methods: Seventy-five pwMS were randomly assigned to an intervention (HIIT: 5 × 1.5-min intervals at 95-100% HR_max, 3 ×/week) or active control group (CG: 24 min continuous exercise at 6

SUBMITTER: Rademacher A 

PROVIDER: S-EPMC7902024 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature