Antibody Responses to Crude Gametocyte Extract Predict <i>Plasmodium falciparum</i> Gametocyte Carriage in Kenya.

ABSTRACT:

Background

Malaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to reduce malaria transmission by targeting the gametocyte reservoir are key to malaria elimination and/or eradication. However, factors that are associated with gametocyte carriage have not been fully explored. Consequently, identifying predictors of the infectious reservoir is fundamental in the elimination campaign.

Methods

We cultured P. falciparum NF54 gametocytes (to stage V) and prepared crude gametocyte extract. Samples from a total of 687 participants (aged 6 months to 67 years) representing two cross-sectional study cohorts in Kilifi, Kenya were used to assess IgG antibody responses by ELISA. We also analyzed

SUBMITTER: Omondi BR 

PROVIDER: S-EPMC7902058 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature