Abnormal liver tests in patients with SARS-CoV-2 or influenza - prognostic similarities and temporal disparities.

ABSTRACT:

Background & aims

Abnormal liver tests are common in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but a possible direct role of the virus in liver injury and its association with short-term outcomes are controversial. Therefore, we aimed to compare the pattern of abnormal liver tests in patients with SARS-CoV-2 with those of patients infected with influenza, a non-hepatotropic respiratory virus, and their association with worse outcomes during hospitalisation.

Methods

We performed a retrospective cohort study of 1,737 hospitalised patients (865 with influenza and 872 with SARS-CoV-2) in a tertiary medical centre. We defined abnormal liver tests as alanine transaminase or aspartate transaminase ≥40 IU/ml at any time-point during hospit

SUBMITTER: Shafran N 

PROVIDER: S-EPMC7902222 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature