Recurrence of head and neck squamous cell carcinoma in relation to high-risk treatment volume.

ABSTRACT:

Background

Locoregional recurrence remains a major cause of failure in head and neck squamous cell carcinoma (HNSCC). Human papilloma virus (HPV)-associated HNSCCs generally have a good prognosis but may recur even after standard photon radiotherapy (RT). Another incentive in observing patterns of recurrence is increased use of highly conformal techniques such as proton therapy. We therefore studied geographic distribution of recurrent tumors in relation to the high-risk treatment volume in a cohort of patients with HNSCC receiving combined modality therapy.

Methods

Medical records of 508 patients diagnosed with HNSCC in 2010-2015 were reviewed. We identified a subgroup that had local and/or regional recurrence at hybrid positron emission tomography (PET)/computed tomography

SUBMITTER: Nissi L 

PROVIDER: S-EPMC7902285 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature