TAS-303 effects on urethral sphincter function in women with stress urinary incontinence: phase I study.

ABSTRACT:

Introduction and hypothesis

TAS-303, which selectively inhibits noradrenaline reuptake, was developed for treating stress urinary incontinence (SUI). The proximal urethra mainly comprises smooth muscle fibers in which α1 adrenergic receptors are abundant. This study was conducted to evaluate the effect of TAS-303 on urethral function and its safety profile in female patients with SUI.

Methods

In total, 16 women (age, 20-64 years) with SUI and > 5.0 g of leakage in the 1-h pad test at screening were randomized and administered the assigned treatment in a double-blind manner. The primary end point was change in the maximal urethral closure pressure (MUCP) at 6 h post-dose. The secondary end point was change in the urethral closure pressure of the entire urethra and each urethr

SUBMITTER: Yono M 

PROVIDER: S-EPMC7902327 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature