The competing risk of death and selective survival cannot fully explain the inverse cancer-dementia association.

ABSTRACT:

Introduction

We evaluated whether competing risk of death or selective survival could explain the reported inverse association between cancer history and dementia incidence (incidence rate ratio [IRR] ≈ 0.62-0.85).

Methods

A multistate simulation model of a cancer- and dementia-free cohort of 65-year-olds was parameterized with real-world data (cancer and dementia incidence, mortality), assuming no effect of cancer on dementia (true IRR = 1.00). To introduce competing risk of death, cancer history increased mortality. To introduce selective survival, we included a factor (prevalence ranging from 10% to 50%) that reduced cancer mortality and dementia incidence (IRRs ranged from 0.30 to 0.90). We calculated IRRs for cancer history on dementia incidence in the simulated cohorts

SUBMITTER: Hayes-Larson E 

PROVIDER: S-EPMC7902336 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature