Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.

ABSTRACT:

Objectives

We obtained preliminary evidence on the efficacy of early prophylaxis on the risk of central venous catheter-associated deep venous thrombosis and its effect on thrombin generation in critically ill children.

Design

Bayesian phase 2b randomized clinical trial.

Setting

Seven PICUs.

Patients

Children less than 18 years old with a newly inserted central venous catheter and at low risk of bleeding.

Intervention

Enoxaparin adjusted to anti-Xa level of 0.2-0.5 international units/mL started at less than 24 hours after insertion of central venous catheter (enoxaparin arm) versus usual care without placebo (usual care arm).

Measurements and main results

At the interim analysis, the proportion of central venous catheter-associated deep venous th

SUBMITTER: Faustino EVS 

PROVIDER: S-EPMC7902342 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature