Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

ABSTRACT: Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of BD medication can partially or fully restore lung function as measured by pulmonary function tests. The genetics of baseline lung function measures taken before BD medication have been extensively studied, and the genetics of the BD response itself have received some attention. However, few studies have focused on the genetics of post-BD lung function. To address this gap, we analyzed lung function phenotypes in 1103 subjects from the Study of African Americans, Asthma, Genes, and Environment, a pediatric asthma case-control cohort, using an integrative genomic analysis approach that combined genotype, locus-specific genetic anc

SUBMITTER: Goddard PC 

PROVIDER: S-EPMC7902343 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature