Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress.

ABSTRACT:

Background

Obesity is a global pandemic characterized by multiple comorbidities, including cardiovascular and metabolic diseases. The aim of this study was to define the associations between blood donor body mass index (BMI) and RBC measurements of metabolic stress and hemolysis.

Study design and methods

The associations between donor BMI (<25 kg/m² , normal weight; 25-29.9 kg/m² , overweight; and ≥30 kg/m² , obese) and hemolysis (storage, osmotic, and oxidative; n = 18 donors) or posttransfusion recovery (n = 14 donors) in immunodeficient mice were determined in stored leukocyte-reduced RBC units. Further evaluations were conducted using the National Heart, Lung, and Blood Institute RBC-Omics blood donor databases of hemolysis (n = 13 317) a

SUBMITTER: Hazegh K 

PROVIDER: S-EPMC7902376 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature