Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults.

ABSTRACT:

Objective

To examine whether the association between dopamine-related genotype and gait speed differs according to frailty status or race.

Design

Cross-sectional population-based study (Cardiovascular Health Study).

Setting

Multicenter study, four U.S. sites.

Participants

Volunteer community-dwelling adults aged 65 years and older, without evidence of Parkinson's disease (N = 3,744; 71 years; 82% White; 39% male).

Measurements

Gait speed (usual pace; m/s), physical frailty (Fried definition), and genetic polymorphism of catechol-O-methyltransferase (COMT; rs4680), an enzyme regulating tonic brain dopamine levels, were assessed. Interaction of COMT by frailty and by race predicting gait speed were tested, and, if significant, analyses were stratified. Mul

SUBMITTER: Mance S 

PROVIDER: S-EPMC7902408 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature